Organozinc Reagents for Facile Synthetic Route to Diflunisal, Fenbufen and Felbinac
نویسندگان
چکیده
Scheme 2. Preparation of Fenbufen Of many organometallics, organozinc reagents have been found to be an excellent reagent for the cross-coupling reactions mainly due to the compatible functional group tolerance. More significantly, most of the organozinc reagents are easily prepared by either the direct insertion of zinc metal or transmetallation with zinc salts. In our continuing study on the preparation and application of organozinc reagents, we have found that several organozinc reagents undergo the cross-coupling reactions with the appropriate coupling partners to give rise to the biologically active compounds under mild conditions. Herein, we would like to report our preliminary results of the preparation of some nonsteroidal anti-inflammatory drugs (NSAIDs) using readily available organozinc reagents.
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